1.04 UTF-8 0 0 0 non-steroidal anti-inflammatory drugs reduce fever and help attenuate inflammation primarily by inhibiting the production of 2 prostaglandins 1 poor control of infection in lepromatous disease is generation of _________ response, characterized by __________ production and a failure of macrophage activation. 2 TH2 IL-4 1 malnutrition, severe combined immunodeficiency and HIV are all due to 2 CD4 T cell deficiency, infection with pneumocyctis carinii and cytomegalovirus 1 what is the resoning behind conjugating a vaccine 2 induction of a t dell dependent antibody response, including memory T cells and memory B cells 1 prednisone and cyclosporin both block ________ 2 production of cytokines 1 complement attracts ____________, lyse _______________ bacteria, and facilitate injections of _________ 2 phagocytes gram-negative microbes 1 MS and insulin-dependent diabetes mellitus are due to ______________ 2 T cells as part of the type IV hypersentivity 1 signals for naive, mature T cell activation 2 CD28 and B7 TCR and MHC IL-2R and IL-2 1 what is the function of CD40 2 important contributor to the inflammatory processes that lead to atherosclerosis and thrombosis (clotting) 1 CD3 subunits complex with ____________ to from a signal trasduction complex that extends into the cytoplasm 2 TCR 1 isotype switching in B cells is influenced by cytokines from type of cells 2 TH2 1 people with SLE will have ___________ and reduced amouts of _________ and ____ in their blood 2 Anti-nuclear antibodies (ANA) C3 and C4 1 innate immunity to viral infections include 2 NK cells interferon alpha and beta 1 late phase hypersensitivity problems are characterized by the influx of what 2 TH2 cells IL4 IL5 eosinophils 1 what are the effects of coriticosteroids inhibit... 2 t cell cytokine production inflammatory cytokine procution by macrophages expresison of adhesion molecules needed for entry of leukocytes inot tissues procution of prostaglandins and leukotrienes 1 how do you treat rheumatoid arthritis and how does it work 2 TNF (tumor necrosis factor) which acts on the vascular endothelium to induce adhesion molucules thereby facilitating neutrophil recruitment into the joints 1 aspirin blocks the procution of ___________ 2 prostaglandins 1 persistent protracted viral infections could be an indicator of .... pt has no probs with bacterial , fungal or parasitic infections 2 a lack of MHC class I molecules 1 what is the effect of IL-12 2 induce TH1 reponse ( and thus inhibit development of IgE) 1 pt with systemic lupus erythematosis and hx of pneumococcal bacteremia makes you think that the pt might have __________ 2 a defect in the classical complement pathway 1 coricosteroids and tacrolimus or cyclosporin A have what in common in their function 2 inhibition of cytokine production 1 initiation of the alternative complement pathway depends on ________________ 2 spontaneous hydrolysis of C3 1 primary funciton of thymic epithelial cells is to facilitate... 2 Negative selection of T cells 1 TNF and IL-1 are both ___________ cytokines 2 pro-inflammatory 1 what are some of the negative effects of TNF-alpha that occur with rheumatoid arthritis 2 damaging capillaries (to release fluid from blood) stimulating monocytes (neutrophils) which infiltrate synovia and cuase damage by releaseing their toxic mediators, including NO and oxygen species, as well as degradative enzymes 1 what is the direct pathway of alloantigen presentation 2 Donor cell (dendritic cell) presents donor peptide to recipeint T cells (acute rejection) 1 what is the indirect pathwasy of alloantigen presentation 2 donor cells apoptose and are engulfed by recipient macrophages or B cells that process the donor HLA and subsequently display recipient HLA with peptides from Donor HLA to recipient CD4 T cells 1 what molecule is involved in the entry of naive T cells into lymph nodes and their interactions with dendritic cells? 2 The intergrin, LFA-1 1 mutations in RAG 1 or 2 genes would disrupt development of what type of cells 2 B and T 1 homozygous deficiency in what receptor conferes resistance to HIV 2 CCR5 1